Abnormalities of Chromosome 7 q and Tac Expression in T Cell

Clonal chromosome abnormalities were demonstrated in 1 3 cases of T cell leukemia with a mature membrane phenotype. The cases comprised two adult T cell lymphoma leukemia (ATLI). five S#{233}zary syndrome (SS), three T prolymphocytic leukemia (T-PLL). and three T chronic lymphocytic leukemia (T-CLL). The presence of clonal chromosome abnormalities in the three cases of T-CLL supports the view that although clinically benign. this disorder probably represents a neoplastic process. Cells from six of 1 1 patients were tested and found to be reactive with monoclonal antibody (McAb) anti-Tac in the absence of mitogens (two ATLI. two 55. and two T-PLL).